menopause tagged posts

How does Estrogen Protect Bones? Unraveling a pathway to menopausal bone loss

Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote survival, resulting in reduced osteoclastic bone resorption and enhanced osteoblastic bone formation. Sema3A-activated sGC-cGMP signaling through Nrp1 protected osteocytes from apoptosis.
Credit: Department of Cell Signaling,TMDU

Women who have reached menopause are at a greater risk of developing osteoporosis, which can lead to bone fractures and long-term impairment of mobility. Studies have suggested a link between reduced bone density and low estrogen levels due to menopause, but the basis for this link is unclear. Researchers found that the protein Sema3A plays a key role in maintaining healthy bones, suggesting a new therapeutic avenue to treat osteoporosis.

Bone is a complex...

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Soy Diets might Increase Women’s Bone Strength

Soy protein improves tibial whole-bone and tissue-level biomechanical properties in ovariectomized and ovary-intact, low-fit female rats. Bone Reports, 2018; 8: 244 DOI: 10.1016/j.bonr.2018.05.002

Soy protein improves tibial whole-bone and tissue-level biomechanical properties in ovariectomized and ovary-intact, low-fit female rats. Bone Reports, 2018; 8: 244 DOI: 10.1016/j.bonr.2018.05.002

Researchers now have discovered through a new animal study that soy protein found in food might counter the negative effects of menopause on bone and metabolic health. Moreover, the researchers believe that soy protein might also have positive impacts on bone strength for women who have not yet reached menopause.

Osteoporosis, decreased physical activity and weight gain are serious health concerns for postmenopausal women...

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