metabolism tagged posts

When should you Eat to Manage your Weight? Breakfast, not Late-Night Snacks

Meal timing alters substrate oxidation

The balance between weight gain and weight gain loss is predominantly determined by what you eat, how much you eat, and by how much exercise you get. But another important factor is often neglected… Published February 27 in the open-access journal PLOS Biology, research conducted by Kevin Kelly, Owen McGuinness, Carl Johnson and colleagues of Vanderbilt University, USA shows that it’s not just how many calories you eat, but WHEN you eat them that will determine how well you burn those calories.

Your daily biological clock and sleep regulate how the food you eat is metabolized; thus the choice of burning fats or carbohydrates changes depending on the time of day or night...

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A New Substance Prevents Vascular Calcification

heating elements covered in limescale
Just as heating elements become covered in limescale, some diseases cause calcification in the soft tissues of the body. (Photograph: Shutterstock)

Researchers at ETH Zurich and ETH spin-off Inositec have developed a new substance to prevent vascular calcification, which affects many patients suffering from chronic kidney disease. As their metabolism is impaired, calcium salts may deposit in soft tissues, such as blood vessels or even the heart valves, causing them to stiffen. This often leads to severe, potentially fatal cardiovascular diseases. However, before patients can benefit from the substance further research and tests must be carried out.

“Calcification occurs when calcium phosphate crystals are deposited in tissue,” explains Jean-Christophe Leroux, Professor of Drug For...

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Cardio Exercise and Strength Training affect Hormones differently

Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans

Strength training and cardio exercise affect the body differently with regard to the types of hormones they release into the blood, new research shows. In a new study published in the scientific Journal of Clinical Investigation – Insight, the researchers show that cardio training on an exercise bike causes 3X as large an increase in the production of the hormone FGF21 than strength training with weights. FGF21 has a lot of positive effects on metabolism.

‘Of course it is very exciting for us researchers to see how different forms of physical activity actually affect the body differently...

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Powering up the Circadian Rhythm

Researchers led by the Salk Institute are the first to discover a protein that controls the strength of the body's circadian rhythms. A mouse liver with a "weak" circadian clock, caused by the targeted deletion of FBXW7 (right), has disrupted the lipid metabolism program and promoted lipid accumulation, compared to the normal liver (left). Credit: Salk Institute

Researchers led by the Salk Institute are the first to discover a protein that controls the strength of the body’s circadian rhythms. A mouse liver with a “weak” circadian clock, caused by the targeted deletion of FBXW7 (right), has disrupted the lipid metabolism program and promoted lipid accumulation, compared to the normal liver (left). Credit: Salk Institute

At noon, levels of genes and proteins throughout your body are drastically different than they are at midnight. Disruptions to this 24-hour cycle of physiological activity are why jet lag or a bad night’s sleep can alter your appetite and sleep patterns for days—and even contribute to conditions like heart disease, sleep disorders and cancers...

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