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Metabolite—global cognitive function analyses flowchart. Step A: Replication and generalization analysis in HCHS/SOL of previously reported single metabolites associated with global cognitive function in BPRHS (Step A). Step B: Replication and generalization testing in HCHS/SOL of association of the metabolite risk score (MRS) constructed in BPRHS with extremes of global cognition. Step C: Generalization of single metabolite associations with global cognitive function in the Atherosclerosis Risk In Communities (ARIC) dataset. Step D: Two-sample Mendelian randomization (MR) analysis to evaluate causal relationships between the single metabolites and global cognitive function. Step E: Associations between the Mediterranean diet and single metabolites...Read More
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