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    metastases tagged posts

    Widespread Tumor Suppression Mechanism Stops Cancer Progression by interfering with cancer cell Metabolism

    August 26, 2021, Categories  Biology/Biotechnology, Health/Medical

    Novel Parkin ubiquitome in cancer.(A) Bioinformatics analysis of predicted protein networks regulated by Parkin ubiquitination in the absence of mitochondrial uncoupling, including cell death (HK1, MCL1, and HMGB1), glucose metabolism involving glycolysis (HK1 and TPI1) and the PPP (TALDO1 and TKT), protein folding (CCT7 and HSPA1A, also known as HSP72), and mitochondrial dynamics (RHOT1, FIS1, and MFN2). Parkin-directed ubiquitination sites (Lys, K) identified by SILAC proteomics in each target protein are indicated. (B) PC3 cells in the presence or absence of Parkin were immunoprecipitated with an antibody to MFN2, and immune complexes were probed with antibodies to ubiquitin (Ub) or MFN2 by Western blotting. IP, immunoprecipitation; IB, immunoblot. (C) The conditions are as in (B) exce...
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    Cancer Spread is increased by a High Fat Diet, ground-breaking evidence shows

    December 8, 2016, Categories  Biology/Biotechnology, Health/Medical

    Targeting metastasis-initiating cells through the fatty acid receptor CD36

    Targeting metastasis-initiating cells through the fatty acid receptor CD36

    A specific protein, CD36 found in the cell membranes of tumour cells, is responsible for taking up fatty acids. This unique CD36 activity and dependence on fatty acids distinguishes metastasis-initiating cells from other tumour cells. The work was published today in the journal Nature. Professor Benitah’s team found CD36 was present on metastatic cancer cells from patients with a range of different tumours including oral tumours, melanoma skin cancer, ovarian, bladder, lung and breast cancer. To confirm its essential role in cancer spread, they added CD36 to non-metastatic cancer cells which then caused the cells to become metastatic.

    “Although we have not yet tested this in all tumour types, we can state that CD36 ...

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    Detecting Cancer Cells before they form Metastases

    November 23, 2015, Categories  Health/Medical

    Target cells (green) stick to the microarray platform (red). Credit: Michael Hirtz / KIT

    Target cells (green) stick to the microarray platform (red). Credit: Michael Hirtz / KIT

    To date, it has been difficult to detect cancer cells in the blood at an early stage: about 1 malignant cell is encountered per billion of healthy cells. “Detection of cancer cells in blood in the early stage of a disease is difficult, because concentrations of the cancer cells are extremely small,” Harald Fuchs explains. “We are searching for the needles in the haystack.” The number of extracted tumor cells allows conclusions to be drawn with respect to the success of therapy and the future course of the disease. Genetic analysis of cells allows therapies to be adapted to the type of cancer to be treated.

    “With our method, we reach a very high hit rate: More than 85% of the extracted cells really are ...

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    Antioxidants can Double the rate of Melanoma Metastasis in mice, new research shows

    October 8, 2015, Categories  Biology/Biotechnology, Health/Medical

    The results reinforce previous findings that antioxidants hasten the progression of lung cancer. People with cancer or an elevated risk of developing the disease should avoid nutritional supplements that contain antioxidants, the researchers say. Given well-established evidence that free radicals can cause cancer, the research community had simply assumed that antioxidants, which destroy them, provide protection against the disease.

    “As opposed to the lung cancer studies, the primary melanoma tumor was not affected,” Professor Bergö says. “But the antioxidant boosted the ability of the tumor cells to metastasize, an even more serious problem because metastasis is the cause of death in the case of melanoma. The primary tumor is not dangerous per se and is usually removed.”

    Experiments ...

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