m1A occurs in GC-rich sequence contexts and in genes with structured 5′ UTRs.
Discovery brings RNA to the fore of epigenetics. A new study finds that RNA, DNA template for protein translation, often appears with an extra letter – and this letter is the regulatory key for control of gene expression. The discovery offers insight into different RNA functions in cellular processes and contributions to the development of disease.
“Epigenetics, the regulation of gene expression beyond the primary information encoded by DNA, was thought until recently to be mediated by modifications of proteins and DNA,” said Prof. Gidi Rechavi. “The new findings bring RNA to a central position in epigenetics.”
The number of modified nucleotides (letters) in RNA is 10X larger than that of the letters found in D...
Read More
Recent Comments