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3D Printing method capable of Producing Highly Uniform ‘Blocks’ of Embryonic Stem Cells

Schematic representation of this research.

Schematic representation of this research.

These cells – capable of generating all cell types in the body – could be used as the ‘Lego bricks’ to build tissue constructs, larger structures of tissues, and potentially even micro-organs. “It was really exciting to see that we could grow embryoid body in such a controlled manner,” explains Wei Sun. “The grown embryoid body is uniform and homogenous, and serves as a much better starting point for further tissue growth.”

The researchers, based at Tsinghua University, Beijing, China, and Drexel University, Philadelphia, USA, used extrusion-based 3D printing to produce a grid-like 3D structure to grow embryoid body with cell viability and rapid self-renewal for 7 days while maintaining high pluripotentcy.

Images of the printed cellular model with grid structure. (A) Full view of the cellular construct. (B) Phase-contrast images demonstrating the cell morphology and distribution of different cell density at day 3, day 5 and day 7. Scale bar: 1 mm.

Images of the printed cellular model with...

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