microbiota tagged posts

A visualization of the changes to the colon and the gut bacteria after eating a low-fiber, Western-type diet and then subsequently eating a diet supplemented with fiber. Credit: Shroeder, et al.

Anyone watching their waistline this holiday season may want to pay attention to what their gut bacteria are eating. It’s not just calories that matter in a healthy diet – it’s fiber that resists digestion by the body but is readily eaten by bacteria in the gut. The amount of fiber in someone’s diet can influence weight gain, blood sugar, insulin sensitivity, and colon health. Two studies with mice, publishing December 21 in the journal Cell Host & Microbe, help shed light on how and why fiber has such a powerful effect on the entire body.

“Once the mechanism is understood, it can be exploited in d...

Highlights • Gut microbes show a dichotomy in ecological strategy for access to nitrogen • Beneficial microbes are overrepresented in the endogenous N source guild • Diets that reduce availability of dietary N to microbes promote healthy aging • Diet impact on host-microbiome interaction can be simplified for modeling

Scientists are one step closer to understanding the link between different diet strategies and gut health, with new research presenting the first general principles for how diet impacts the microbiota. Researchers from the University of Sydney have found that the availability of intestinal nitrogen to microbes in the gut plays a key role in regulating interactions between gut microbes and their host animal.

“This research really lays the groundwork for future modellin...

agitating host-microbiota interactions to cause low-grade gut inflammation can promote colon carcinogenesis

Emulsifiers, added to most processed foods to aid texture and extend shelf life, can alter intestinal bacteria in a manner that promotes intestinal inflammation and colorectal cancer, according to a new study. The findings, published in the journal Cancer Research, show regular consumption of dietary emulsifiers in mice exacerbated tumor development. Colorectal cancer, the fourth leading cause of cancer-related deaths worldwide, was responsible for about 700,000 deaths in 2012. There is increasing awareness that intestinal microbiota play a role in driving colorectal cancer.

The microbiota is also a key factor in driving Crohn’s disease and ulcerative colitis, the two most common for...

Andreas Bäumler and his team discovered how pathogens manipulate the intestinal environment to favor their own growth.

Why do some foodborne bacteria make us sick? A paper published Sept. 16 in the journal Science has found that pathogens in the intestinal tract cause harm because they benefit from immune system responses designed to repair the very damage to the intestinal lining caused by the bacteria in the first place. “The finding is important because it explains how some enteric pathogens can manipulate mammalian cells to get the oxygen they need to breathe,” said Prof. Andreas Bäumler, UC Davis School of Medicine...