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Neuron groups in mice spinal cord found responsible for encoding different types of pain

Study unveils groups of neurons in the mouse spinal cord that encode different types of pain
Capturing ensembles encoding mechanical and heat pain in the spinal dorsal horn. Credit: Zhang et al. (Nature Neuroscience, 2025).

Humans and other animal species can experience many types of pain throughout the course of their lives, varying in intensity, unpleasantness, and origin. Several past neuroscience studies have explored the neural underpinnings of pain, yet the processes supporting the ability to distinguish different types of physical pain are not fully understood.

In most vertebrates, painful sensations are known to arise from the nervous system, which includes the brain, an intricate network of nerves and the spinal cord...

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