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    microRNA tagged posts

    Tiny Genetic Switches found in Lizard Tail Regeneration

    May 6, 2016, Categories  Biology/Biotechnology, Health/Medical

    Experimental design of microRNA analysis of lizard tail regeneration. a: Image of a green anole lizard with a fully regenerated tail (arrow at break point). b: A 25 dpa regenerating tail was divided into three equally sized segments, with the distal regenerating tip and proximal regenerating base collected for microRNA sequencing (sequenced each for the regenerating tail tip and base, n = 3 per pool). For qRT-PCR analysis, five equally sized segments were collected (n = 4). c: Venn diagram showing the distribution of microRNAs expressed in the brain, skeletal muscle, and 25 dpa regenerating tail tip and base (minimum count of 1)

    Experimental design of microRNA analysis of lizard tail regeneration. a: Image of a green anole lizard with a fully regenerated tail (arrow at break point). b: A 25 dpa regenerating tail was divided into three equally sized segments, with the distal regenerating tip and proximal regenerating base collected for microRNA sequencing (sequenced each for the regenerating tail tip and base, n = 3 per pool). For qRT-PCR analysis, five equally sized segments were collected (n = 4). c: Venn diagram showing the distribution of microRNAs expressed in the brain, skeletal muscle, and 25 dpa regenerating tail tip and base (minimum count of 1)

    Findings from lizards may impact future therapies to regrow organs in humans...

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    Nano-Shells Deliver Molecules that Tell Bone to Repair itself

    January 14, 2016, Categories  Biology/Biotechnology, Health/Medical, Physics

    The polymer sphere delivers the microRNA into cells already at the wound site, which turns the cells into bone repairing machines. Credit: Peter Ma

    The polymer sphere delivers the microRNA into cells already at the wound site, which turns the cells into bone repairing machines. Credit: Peter Ma

    Scientists at the University of Michigan have developed a polymer sphere that delivers a molecule to bone wounds that tells cells already at the injury site to repair the damage. Using the polymer sphere to introduce the microRNA molecule into cells elevates the job of existing cells to that of injury repair by instructing the cells’ healing and bone-building mechanisms to switch on, said Prof Peter Ma.

    Using existing cells to repair wounds reduces the need to introduce foreign cells – a very difficult therapy because cells have their own personalities, which can result in the host rejecting the foreign cells, or tumors...

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