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    miRNA Inhibitor tagged posts

    New miRNA Inhibitor could Extinguish the ‘Inflammatory Fire’ that Stroke causes in the Brain

    October 30, 2024, Categories  Biology/Biotechnology, Health/Medical

    Novel gamma PNA based miRNA-141-3p inhibitors (syPNA-141) reduced brain damage (image on right with less atrophy) after stroke in mouse model of ischemic stroke.
    Novel gamma PNA based miRNA-141-3p inhibitors (syPNA-141) reduced brain damage (image on right with less atrophy) after stroke in mouse model of ischemic stroke. (Courtesy of Verma laboratory image).

    It’s been more than three decades, but still there are only two treatments for a stroke: either rapid use of a clot-busting medication called tPA or surgical removal of a clot from the brain with mechanical thrombectomy. However, only 5% to 13% percent of stroke cases are actually eligible for these interventions.

    “We need to be persistent with our research to find a new therapy for stroke,” says Rajkumar Verma, M.Pharm., Ph.D., assistant professor, Department of Neuroscience at UConn School of Medicine working in cross-campus collaboration with Professor Raman Bahal Ph.D...

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