mitochondria tagged posts

The new findings could lead to better treatments for rheumatoid arthritis, lupus and other inflammatory diseases – and may even help us slow aging.

Researchers have discovered how “leaky” mitochondria can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis. Scientists may be able to leverage the findings to develop better treatments for those diseases, improve our ability to fight off viruses and even slow aging.

The new discovery reveals how genetic material can escape from our cellular batteries, known as mitochondria, and prompt the body to launch a damaging immune response...

The number of people with obesity has nearly tripled since 1975, resulting in a worldwide epidemic. While lifestyle factors like diet and exercise play a role in the development and progression of obesity, scientists have come to understand that obesity is also associated with intrinsic metabolic abnormalities.

Now, researchers from University of California San Diego School of Medicine have shed new light on how obesity affects our mitochondria, the all-important energy-producing structures of our cells.

In a study published in Nature Metabolism, the researcher...

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of diseases relating to mitochondrial dysfunction, such as cancer and autoimmune disorders. Mitochondria are organelles that supply most of the chemical energy needed to power cells’ biochemical reactions.

The study is published in the journal PNAS. The researchers analyzed more than 130 proteins released by Coxiella burnetii when this bacterium invades host cells, and found at least one to be capable of prolonging cell longevity by acting directly on mitochondria.

After invading host cells, C...

The connection between exercise and inflammation has captivated the imagination of researchers ever since an early 20th-century study showed a spike of white cells in the blood of Boston marathon runners following the race.

Now, a new Harvard Medical School study published in Science Immunology may offer a molecular explanation behind this century-old observation.

The study, in mice, suggests that the beneficial effects of exercise may be driven, at least partly, by ...