mitochondria tagged posts

Researchers at the Universities of Bonn and Singapore have discovered a new intracellular “smoke detector.” The sensor warns of damage to the mitochondria. If it does not function properly, chronic skin diseases can result. The sensor may also be important for unimpaired heart and bowel function. The results have now been published in the journal Nature Immunology.

Every cell in the body has numerous sensors that monitor its function...

As we age, the end caps of our chromosomes, called telomeres, gradually shorten. Now, Salk scientists have discovered that when telomeres become very short, they communicate with mitochondria, the cell’s powerhouses. This communication triggers a complex set of signaling pathways and initiates an inflammatory response that destroys cells that could otherwise become cancerous.

The findings, published in Nature on February 8, 2023, could lead to new ways of preventing and treating cancer as well as designing better interventions to offset the harmful consequences of aging.

The discovery is the result of a collaboration between co-senior authors ...

The findings shed a rare light on mitoribosomes, the unique ribosomes found within the cell’s mitochondria. Ribosomes, the tiny protein-producing factories within cells, are ubiquitous and look largely identical across the tree of life. Those that keep bacteria chugging along are, structurally, not much different from the ribosomes churning out proteins in our own human cells.

But even two organisms with similar ribosomes may display significant structural differences in the RNA and protein components of their mitoribosomes...

Researchers have solved a decade-long mystery about a critical protein linked to Parkinson’s disease that could help to fast-track treatments for the incurable disease.

The research, published in Nature, has for the first time produced a ‘live action’ view of the protein, called PINK1, in exquisite molecular detail. The discovery explains how the protein is activated in the cell, where it is responsible for initiating the removal and replacement of damaged mitochondria...