Researchers at Duke University Medical Center and Wake Forest University School of Medicine have identified ALDH4A1, a Mitochondrial proline-metabolizing enzyme, as a third structural component of the mitochondrial pyruvate carrier (MPC) complex. Forming a trimeric assembly with MPC1 and MPC2, ALDH4A1 maintains MPC integrity and facilitates pyruvate import into mitochondria.
Mitochondrial pyruvate import serves as a critical step in cellular energy metabolism, linking cytosolic glycolysis to mitochondrial oxidative phosphorylation...
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