Proposed mechanism of skeletal muscle mitochondria involvement in sarcopenia
Muscle wastage and loss of strength, ie sarcopenia causes loss of quality of life. At about 55 years old, people begin to lose muscle mass, this loss continues into old age, at which point it becomes critical. The underlying causes of sarcopenia are unknown and thus no treatment is available for this condition. A study has discovered that Mitofusin 2 is required to preserve healthy muscles in mice. This protein could serve as a therapeutic target to ameliorate sarcopenia in the elderly.
They demonstrate that low activity of this protein in 24-month old mice (equivalent of a person aged 80) is directly associated with muscle wastage and sarcopenia observed...
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