A schematic showing how a human monoclonal antibody containing a loop structure (CDR-H3) inspired by antibodies found naturally in camels can bind to matrix metalloproteinase 14, which has been shown to play a significant role in several types of cancer.
Researchers at the University of California, Riverside have camels and llamas to thank for their development of a new cancer treatment that is highly selective in blocking the action of faulty matrix metalloproteinases (MMPs). MMPs are a group of 26 closely related proteinases (enzymes that break down other proteins) that are essential in tissue regeneration and other normal cellular processes. However, when a tumor grows, certain MMPs are over-produced, allowing cancer cells to spread to other parts of the body.
Assistant professor Xin Ge...
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