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    New Study Unveils Epigenetic ‘Traffic Lights’ Controlling Stop and Go for Gene Activity

    March 2, 2023, Categories  Biology/Biotechnology, Health/Medical

    Extended Data Fig. 11
    H3K4me3 facilitates the recruitment of factors regulating the release of paused RNAPII at the +1 nucleosome. The H3K4me3 at promoter regions is highly dynamic, and it is maintained by an equilibrium between SET1/COMPASS complexes and KDM5 demethylases at highly transcribed genes. The rapid turnover of H3K4me3 ensures that the pausing step is a highly regulated process by Integrator Complex Subunit 11 (INTS11), where an increase in H3K4me3 leads to a decrease in RNAPII pausing and acute depletion leads to an increase RNAPII pausing.

    A major new study in the journal Nature reveals a ‘traffic light’ mechanism controlling genetic activity within cells – a system which could potentially be targeted by cancer drugs already in development...

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