•IFNγ and TLR signaling causes cell death via caspase-8, iNOS, and BAX/BAK
•Caspase-8 regulates BCL2 and iNOS expression to activate BAX/BAK independent of BID
•iNOS causes caspase-8 cleavage and destabilizes the BAX/BAK inhibitors MCL1 and A1
•Caspase-8 and iNOS promote severe disease upon SARS-CoV-2 infection of mice
A WEHI-led study has identified a molecular ‘culprit’ responsible for causing damaging levels of cell death and inflammation in the body. The findings could lead to improved treatment options for a range of conditions driven by inflammatory cell death, including the SARS-CoV-2 virus.
Cell death is an important part of the body’s immune response to infection...
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