This confocal image shows the mossy cell commissural projections (red) and neural stem cells (in green) in the adult mouse dentate gyrus region of the brain.
Credit: Song Lab, UNC School of Medicine
Scientists showed that ‘mossy cells’ in the hippocampus regulate local stem cells to control their production of new neurons, which is important for normal learning and memory, stress response, and mood regulation. Such neurogenesis in the adult brain is disrupted in many common conditions including Alzheimer’s disease, depression, anxiety, schizophrenia, traumatic brain injury, and some forms of epilepsy.
Targeting mossy cells to reverse such disruption may therefore offer a new strategy for treating these conditions”The hope is we could manipulate even a small number of mossy cells to restore ...
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