mtd/OXR1 tagged posts

Scientists Identify how Dietary Restriction Slows Brain Aging and Increases Lifespan

Scientists identify how dietary restriction slows brain aging and increases lifespan
mtd interacts with the retromer complex and is required for retromer maintenance. Credit: Nature Communications (2024). DOI: 10.1038/s41467-023-44343-3

Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Buck Institute for Research on Aging scientists have uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.

“When people restrict the amount of food that they eat, they typically think it might affect their digestive tract or fat buildup, but not necessarily about how it affects the brain,” said Kenneth Wilson, Ph.D...

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