multiple sclerosis (MS) tagged posts

New insight into the immune signals driving inflammation in multiple sclerosis

New insight into the immune signals driving inflammation in multiple sclerosis
Representative confocal microscopy image of a cross-section of the whole spinal column of an EAE animal co-transferred with control (red) and Tgfbr1-KO (green) cells. Credit: de la Rosa, Kendirli et al

Multiple sclerosis (MS) is a chronic neurological disease characterized by nerve damage and consequent impairments in vision, movement, balance and mental function. In MS, the immune system mistakenly starts attacking myelin, the protective sheath that surrounds axons (i.e., nerve fibers) in the brain, spinal cord and optic nerves.

Macrophages, immune cells responsible for detecting damaged cells, germs or other debris in the central nervous system (CNS) and eliminating them, have been found to play a key role in MS...

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Immunotherapy Eliminates Disease-causing Cells in Mice with MS-like Disease

Successful cancer treatment approach extended to autoimmune disease. Researchers have shown that the cancer therapy known as CAR-T can be applied to multiple sclerosis (MS), an autoimmune disease of the nervous system. The findings extend the powerful tool of immunotherapy to autoimmune diseases, a class of diseases that are often debilitating and difficult to treat.

The cancer therapy known as CAR-T has revolutionized treatment of some blood cancers since it was introduced in 2017. The therapy uses genetically altered immune cells to home in on cancer cells and destroy them.

Now, studying mice with an autoimmune disease similar to multiple sclerosis (MS), researchers at Washington University School of Medicine in St...

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