multiple sclerosis tagged posts

It is thus possible to encourage regeneration of the myelin sheath by inhibiting the action of PTPRZ in endogenous oligodendrocyte precursor cells, indicating a new potential treatment for demyelinating diseases. Normally, myelin is repaired, even if damaged, but the mechanism that controls remyelination was not well understood. In addition, in demyelinating diseases eg multiple sclerosis, the myelin sheath does not recover from damage and gets worse, finally leading to symptoms such as vision loss, limb numbness, and movement disorders. The research group of Professor Masaharu Noda and colleagues of the National Institute for Basic Biology, performed a detailed examination of the remyelinating process of damaged myelin using disease model mice...

Vitamin D pathway. In blue are the genes containing, or in proximity to, SNPs that were genome-wide significant for 25OHD level in SUNLIGHT (n = 33,996). The p-values for the association with 25OHD level were 1.9 × 10−109 for GC, 2.1 × 10−27 for DHCR7, 3.3 × 10−20 for CYP2R1, and 6.0 × 10−10 for CYP24A1. Note that each gene plays an independent role in modulating the level of 25OHD. Kidney and liver images credit: https://openclipart.org/. doi:10.1371/journal.pmed.1001866.g002

Genetic findings support observational evidence that lower vitamin D levels are associated with increased risk of multiple sclerosis...