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    muscular dystrophy tagged posts

    Moths and Magnets could Save Lives

    November 16, 2018, Categories  Biology/Biotechnology, Health/Medical

    Rice University bioengineers use a magnetic field to activate nanoparticle-attached baculoviruses in a tissue. The viruses, which normally infect alfalfa looper moths, are modified to deliver gene-editing DNA code only to cells that are targeted with magnetic field-induced local transduction.
    Credit: Laboratory of Biomolecular Engineering and Nanomedicine/Rice University

    Experimental therapy could repair mutations that cause genetic diseases. Bioengineers have combined a virus that infects moths with magnetic nanoparticles to create a potential new therapy for inherited genetic diseases like muscular dystrophy, sickle cell, cystic fibrosis, spinal muscular atrophy and some forms of cancer.

    Rice University bioengineer Gang Bao has combined magnetic nanoparticles with a viral container drawn ...

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    Protein found to Bolster Growth of Damaged Muscle tissue

    July 19, 2016, Categories  Biology/Biotechnology, Health/Medical

    Activating [beta]1-integrin in mdx mice ameliorates dystrophic pathology and restores muscle strength.

    Activating β1-integrin in mdx mice ameliorates dystrophic pathology and restores muscle strength.

    This could potentially contribute to Rx for muscle degeneration caused by old age and diseases such as muscular dystrophy. A particular type of protein called integrin is present on the stem cell surface and used by stem cells to interact with, or “sense” their surroundings. How stem cells sense their surroundings, also known as the stem cell “niche,” affects how they live and last for regeneration. The presence of the protein β1-integrin was shown to help promote the transformation of those undifferentiated stem cells into muscle after the tissue has degraded, and improve regenerated muscle fiber growth as much as 50%.

    The experiment shows that β1-integrin – one of 28 types of integrin – mai...

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    Gene Therapy treats all Muscles in the Body in Muscular Dystrophy Dogs

    October 22, 2015, Categories  Biology/Biotechnology, Health/Medical

    The dystrophin protein connects the cytoskeleton of muscle fibers with its N-terminal actin-binding domain and the extra-cellular matrix via a cysteine-rich C-terminal domain that binds dystroglycan, which in turn is bound to laminin 2. Between these two functional domain lies a large central domain that consists of 24 spectrin like repeats.

    The dystrophin protein connects the cytoskeleton of muscle fibers with its N-terminal actin-binding domain and the extra-cellular matrix via a cysteine-rich C-terminal domain that binds dystroglycan, which in turn is bound to laminin 2. Between these two functional domain lies a large central domain that consists of 24 spectrin like repeats.

    Human clinical trials are next step. Muscular dystrophy, which affects approximately 250,000 people in the US, occurs when damaged muscle tissue is replaced with fibrous, fatty or bony tissue and loses function. For years, scientists have searched for a way to successfully treat the most common form of the disease, Duchenne Muscular Dystrophy (DMD), which primarily affects boys...

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