[NAD+] tagged posts

Neuroprotective Activity of NR in DPN Can be Monitored by Corneal Confocal Microscopy.

A naturally occurring vitamin, nicotinamide riboside (NR), can lower BSL, reduce fatty liver, and prevent peripheral nerve damage in mouse models of prediabetes and type 2 diabetes (T2D), according to a new study. The findings provide a scientific rationale for conducting human trials to test the effects of NR on metabolic disorders including prediabetes and T2D, as well as obesity, fatty liver disease, and neuropathies.

NR is a vitamin precursor of NAD+, an important cellular metabolite that is required for cells to convert fuel into energy, but which declines with age. NR is currently attracting a great deal of attention for its potential role in improving metabolic health and healthy aging...

Nicotinamide Riboside (NR)

Nicotinamide riboside rejuvenates stem cells, allowing better regeneration processes in aged mice. As mice, like all mammals, age, the regenerative capacity of certain organs (eg liver and kidneys) and muscles (including the heart) diminishes. Their ability to repair them following an injury is also affected. This leads to many of the disorders typical of aging.

Hongbo Zhang wanted to understand how the regeneration process deteriorated with age. To do so, he teamed up with colleagues from ETH Zurich, the Uni of Zurich and universities in Canada and Brazil. Through several markers, he was able to identify the molecular chain that regulates how mitochondria function and how they change with age...

VitB3 3D model

It will allow for novel drug development for obesity, diabetes type II and related metabolic diseases. A small molecule N1-methylnicotinamide prevents metabolic complications caused by a high-fat diet.

“Our laboratory investigates the metabolic effects of nicotinamide adenine dinucleotide [NAD+], a metabolite derived from a form of vitamin B3 called nicotinamide,” explained assistant Prof Pavlos Pissios. NAD+ is central to intermediary metabolism, the intracellular process by which food is converted into cellular components in the body.

“Like reservatrol, which is found in red wine, NAD+ boosts the effects of the protein sirtuin 1 [Sirt1], which is known to provide many health benefits,” said Pissios...