NAFLD tagged posts

Scientists find that a Special Omega-3 Lipid might Prevent Fatty Liver disease

Detection of the lysolipid transporter Mfsd2a in hepatocytes, stained green, in proximity to a bile duct, stained magenta. (Credit:  Chin Cheen Fei)

Long-running research by Duke-NUS Medical School into the omega-3 transporter protein Mfsd2a has shown that it plays a key role in a specific mechanism that prevents the liver from storing too much fat from food. Published in the Journal of Clinical Investigation, this latest study by Duke-NUS and collaborators from Singapore General Hospital (SGH) signals the possibility that a dietary supplement could be developed to help prevent non-alcoholic fatty liver disease (NAFLD).

Eating too much fatty food increases the risk of many health problems, including cardiovascular disease, obesity, diabetes and NAFLD...

Read More

How Regular Exercise can Protect Against Fatty Liver Asociated Diseases

 Training downregulates acetyl-CoA-generating pathways in the liver of high-energy diet-fed mice. Abundance of transcripts (gray/blue filled bars) and proteins (blank bars) related to glucose/fructose degradation, mitochondrial pyruvate metabolism, acetyl-CoA conversion and fatty acid synthesis. The mean Â± SD values for n = 6–8 are shown. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 for diet, training or interaction by two-way ANOVA as indicated. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 for diet, #p < 0.05, ##p < 0.01 for training by Tukey HSD multiple comparisons test. CON = control diet, HED = high-energy diet, SED = sedentary, TRAIN = treadmill training.

Exercise not only trains the muscles but can also prevent the develop...

Read More

Excessive Fructose Consumption may cause a Leaky Gut, leading to Fatty Liver disease

High fructose corn syrup is a ubiquitous food sweetener and linked to numerous diseases and public health issues. Photo credit: Pixabay

Excessive consumption of fructose — a sweetener ubiquitous in the American diet — can result in non-alcoholic fatty liver disease (NAFLD), which is comparably abundant in the United States. But contrary to previous understanding, researchers at University of California San Diego School of Medicine report that fructose only adversely affects the liver after it reaches the intestines, where the sugar disrupts the epithelial barrier protecting internal organs from bacterial toxins in the gut.

Developing treatments that prevent intestinal barrier disruption, the authors conclude in a study published August 24, 2020 in Nature Metabolism, could protect th...

Read More

Lab-on-a-Chip may help identify New Treatments for Liver Disease

Microfluidic progressive NAFLD platform.

Investigators have developed a ‘lab on a chip’ technology that can simulate different levels of Non-alcoholic Fatty Liver Disease progression. Non-alcoholic fatty liver disease (NAFLD) – the accumulation of liver fat in people who drink little or no alcohol – is increasingly common around the world, and in the United States, it affects between 30 and 40 percent of adults. Currently, there are no approved drugs for the treatment of NAFLD, which is predicted to soon become the main cause of chronic liver problems and the need for liver transplantation.

Now a team led by investigators at Massachusetts General Hospital (MGH) has developed a “lab on a chip” technology that can simulate different levels of NAFLD progression in cells across a sing...

Read More