Neutrophils mediate delivery of nanoparticles (NPs) across blood vessel barrier into the tumor tissues after acute inflammation induced by photosensitization (PS).
Technique targets disease, spares nearby tissues. For the first time, WSU researchers have demonstrated a way to deliver a drug to a tumor by attaching it to a white blood cell. The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues. A team led by Zhenjia Wang, an assistant professor of pharmaceutical sciences attached a nanoscale particle to a WBC. The showed they could get a drug past the armor of blood vessels that typically shield a tumor. This has been a major challenge in nanotechnology drug delivery.
Wang implanted a tumor on the flank of a mouse commonly chosen as...
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