Top, from left: Dr. Wan Hee Yoon and Dr. Hugo Bellen. Bottom, from left: Dr. James R. Lupski and Dr. Michael F. Wangler.
An international team has discovered that the gene, OGDHL, a key protein required for normal function of the mitochondria – the energy-producing factory of the cell – and its chaperone, nardilysin (NRD1) are linked to progressive loss of neurological function in humans. Working with the fruit fly, an experimental animal model in the lab, the scientists found a mechanism by which misregulation of mitochondrial function leads to neurodegeneration. The results appear in Neuron.
“In our research we look for genes whose loss of function results in deterioration of neurological functions in the fruit fly Drosophila melanogaster,” said Dr...
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