NCAM1 tagged posts

Body Versus Brain: New evidence for an Autoimmune cause of Schizophrenia

Cell-based assay to detect the anti-NCAM1 autoantibody
NCAM1 is induced only in green cells (HeLa cells). Serum from patients with anti-NCAM1 autoantibody react only to green cells (framed in red).

Researchers have found that some people with schizophrenia have autoantibodies — which are made by the immune system and recognize the body’s own proteins, rather than outside threats such as viruses or bacteria — against NCAM1, a protein that’s importa.nt for communication between brain cells. The patients’ autoantibodies also caused schizophrenia-related behaviors in mice. These findings may improve the diagnosis and treatment of a subset of patients with schizophrenia.

Schizophrenia is a disorder that affects how people act, think, and perceive reality...

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