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    neurodegenerative diseases tagged posts

    An at-home smell test could pave the way for early detection of Alzheimer’s disease

    March 26, 2025, Categories  Biology/Biotechnology, Health/Medical

    An at-home smell test could pave the way for early detection of Alzheimer's disease
    AROMHA Brain Health Test. Following online prescreening and online consent, the web-based program instructs you through the 5 bilingual (English / Spanish) cards (A). Card A comprises a practice odor P followed by the 9 odor labels comprising the OPID9 test. Adjacent in the blue box (B) is the workflow for these tests as directed by the testyourbrainhealth.com software to generate the OPID9, OPID9noguess, and average intensity scores. After a 10-minute break, participants are instructed to work through Cards B and C using the workflow in the green box (B) to generate the POEM, OPID18, and OPID18noguess scores. Then participants are instructed to move on to Cards D and E using the workflow in the purple box (B) to generate an OD10 odor discrimination score. Credit: Scientific Reports (202...
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    Scientists Identify how Dietary Restriction Slows Brain Aging and Increases Lifespan

    January 14, 2024, Categories  Biology/Biotechnology, Health/Medical

    Scientists identify how dietary restriction slows brain aging and increases lifespan
    mtd interacts with the retromer complex and is required for retromer maintenance. Credit: Nature Communications (2024). DOI: 10.1038/s41467-023-44343-3

    Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Buck Institute for Research on Aging scientists have uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.

    “When people restrict the amount of food that they eat, they typically think it might affect their digestive tract or fat buildup, but not necessarily about how it affects the brain,” said Kenneth Wilson, Ph.D...

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    Researcher takes another step toward discovering how a Brain Molecule could Halt MS

    February 3, 2023, Categories  Biology/Biotechnology, Health/Medical

    Fractalkine appears to trigger repair of brain damage caused by the disease. A University of Alberta researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases.

    Multiple sclerosis is an autoimmune disease in which the myelin, or fatty lining of nerve cells, is eroded, leading to nerve damage and slower signalling between the brain and the body. MS symptoms range from blurred vision to complete paralysis, and while there are treatments, the causes are not fully understood and nothing exists to reverse the disease process. More than 90,000 Canadians live with MS, according to the MS Society.

    In new research published in Stem Cell Reports, Anastas...

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    Study finds how our Brains turn into Smarter Disease Fighters

    February 2, 2023, Categories  Biology/Biotechnology, Health/Medical

    This shows the outline of a head
    When microglia are healthy, they serve as the central nervous system’s resident front-line disease warriors. Image is in the public domain

    Immune cell discovery a new attack on Alzheimer’s, neurological disorders. Combating Alzheimer’s and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of Pennsylvania have found a way to safely thwart the brain’s resistance to them, vaulting a key hurdle in the quest.

    Their discovery about brain cells called microglia heralds myriad possibilities for treating and even preventing neurodegenerative disorders. The team’s paper appears in the Journal of Experimental Medicine.

    When microglia are healthy, ...

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