neurodegenerative diseases tagged posts

Obstructing lymphatic vessels (in green) in a mouse model of Alzheimer’s disease significantly increased the accumulation of harmful plaques in the brain. “What was really interesting is that with the worsening pathology, it actually looks very similar to what we see in human samples in terms of all this aggregation of amyloid protein,” said researcher Jonathan Kipnis, PhD. Credit: Courtesy Kipnis lab

Faulty brain plumbing to blame in Alzheimer’s, age-related memory loss – and can be fixed. By improving the function of the lymphatic vessels, scientists at the University of Virginia School of Medicine have dramatically enhanced aged mice’s ability to learn and improved their memories...

These are primary cortical neurons cultured on the surface of an array of optoelectronic nanowires. Here a neuron is pulling the nanowires, indicating the the cell is doing well on this material. Credit: UC San Diego

With high-resolution retinal prosthesis built from nanowires and wireless electronics, engineers are one step closer to restoring neurons’ ability to respond to light. The researchers demonstrated this response to light in a rat retina interfacing with a prototype of the device in vitro. The technology could help tens of millions of people worldwide suffering from neurodegenerative diseases that affect eyesight, including macular degeneration, retinitis pigmentosa and loss of vision due to diabetes.

Despite tremendous advances in the development of retinal prostheses over the ...