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    neurological disorders tagged posts

    Hippocampus MRI
    Confocal image of a mouse brain tissue shows the astrocytes (red) and neurons (green). (UCR/Ethell lab)

    A team led by a biomedical scientist at the University of California, Riverside has found a new mechanism responsible for the abnormal development of neuronal connections in the mouse brain that leads to seizures and abnormal social behaviors.

    The researchers focused on the hippocampus, which plays an important role in learning and social interactions; and synapses, specialized contacts between neurons.

    Each neuron in the brain receives numerous excitatory and inhibitory synaptic inputs...

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    Night Owls have higher risk of Dying Sooner

    April 12, 2018, Categories  Biology/Biotechnology, Health/Medical

    Late to Bed, Early to Die? Night Owls May Die Sooner

    Kristen L. Knutson, Malcolm von Schantz. Associations between chronotype, morbidity and mortality in the UK Biobank cohort. Chronobiology International, 2018; 1 DOI: 10.1080/07420528.2018.1454458

    Evening types have 10% higher risk of dying than morning counterparts. Night owls” – people who like to stay up late and have trouble dragging themselves out of bed in the morning – have a higher risk of dying sooner than “larks,” people who have a natural preference for going to bed early and rise with the sun, according to a new study from Northwestern Medicine and the University of Surrey in the United Kingdom (UK). In the study sample, 50,000 people were more likely to die in the 6½ -year period sampled.

    “Night owls trying to live in a morning lark world may have health consequences for their...

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    Drug Delivery Technique Bypasses BBB may help many patients with Neurological Conditions

    October 20, 2015, Categories  Biology/Biotechnology, Environment/Geology, Health/Medical

    Drugs used to treat a variety of central nervous system diseases may be administered through the nose and diffused through an implanted mucosal graft (A, in red) to gain access to the brain. Under normal circumstances, there are multiple layers within the nose that block the access of pharmaceutical agents from getting to the brain including bone and the dura/arachnoid membrane, which represents part of the blood-brain barrier (B). After endoscopic skull base surgery (C), all of these layers are removed and replaced with a nasal mucosal graft, which is 1,000 times more porous than the native blood-brain barrier. Consequently, these grafts may be used to deliver very large drugs, including proteins, which would otherwise be blocked by the blood-brain barrier. Credit: Garyfallia Pagonis and Benjamin S. Bleier, M.D.

    Drugs used to treat a variety of central nervous system diseases may be administered through the nose and diffused through an implanted mucosal graft (A, in red) to gain access to the brain. Under normal circumstances, there are multiple layers within the nose that block the access of pharmaceutical agents from getting to the brain including bone and the dura/arachnoid membrane, which represents part of the blood-brain barrier (B). After endoscopic skull base surgery (C), all of these layers are removed and replaced with a nasal mucosal graft, which is 1,000 times more porous than the native blood-brain barrier. Consequently, these grafts may be used to deliver very large drugs, including proteins, which would otherwise be blocked by the blood-brain barrier...

    Read More