neuropathic pain tagged posts

A newly identified link between chronic pain and lung cancer in mice offers hope for pain management. A new study points to possible new treatments for chronic pain with a surprising link to lung cancer. Findings of the research, conducted in laboratory mouse models, open up multiple therapeutic opportunities that could allow the world to improve chronic pain management and eclipse the opioid epidemic.

Pain is an important alarm system that alerts us to tissue damage and prompts us to withdraw from harmful situations...

A typical Western high-fat diet can increase the risk of painful disorders common in people with conditions such as diabetes or obesity, according to a groundbreaking paper authored by a team led by The University of Texas Health Science Center at San Antonio, also referred to as UT Health San Antonio.

Moreover, changes in diet may significantly reduce or even reverse pain from conditions causing either inflammatory pain — such as arthritis, trauma or surgery — or neuropathic pain, such as diabetes. The novel finding could help treat chronic-pain patients by simply altering diet or developing drugs that block release of certain fatty acids in the body.

The paper, more than five years in the making, was published in the June edition of the journal Nature Metabolism by a collabora...

Rats were exposed to room light and fitted with contact lenses, one shown here, that allowed the green spectrum wavelength to pass through the lenses. (Photo: Bob Demers/UANews)

Chronic pain afflicts over 100 million people across the US. But now researchers at the University of Arizona have found promise in a novel, non-pharmacological approach to managing chronic pain – treating it with green light-emitting diodes (LED). In the study, rats with neuropathic pain that were bathed in green LED showed more tolerance for thermal and tactile stimulus than rats that were not bathed in green LED. In both cases no side effects from the therapy were observed, nor was motor or visual performance impaired. The beneficial effects lasted for 4 days after the rats’ last exposure to the green LED...

Lack of antinociceptive tolerance of YHS (200 mg/kg) in the tail flick assay (n = 7–8).

Root extracts from the flowering herbal plant Corydalis yanhusuo, or YHS, has widely used for centuries as a pain treatment. Yet few studies have investigated how it works on different forms of pain, and little is known about its molecular mechanisms. In a new study, Olivier Civelli, professor and chair of pharmacology at the University of California, Irvine et al show how YHS effectively treats different forms of pain. Most notably it can reduce chronic neuropathic pain which is poorly treated with common medicines. They also show that YHS seems to not lose its potency over time, as happens with many analgesics.

The researchers analyzed YHS pain relief properties in mouse tests that monitor acute, pe...