Researchers have discovered that gene variants associated with risk of developing Alzheimer’s disease disturb the brain’s natural protective mechanism against the condition.
The brain has a natural protective mechanism against Alzheimer’s disease, and researchers at Baylor College of Medicine, Texas Children’s Hospital and collaborating institutions have discovered that gene variants associated with risk of developing the disease disturb the protective mechanism in ways that can lead to neurodegeneration. The researchers also showed in a fruit fly model of the condition that a chemical known as ABCA1 agonist can restore certain alterations of the brain protective mechanism.
The team reveals evidence supporting reactive oxygen species (ROS), natural byproducts of cellular metabol...
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