IGF-1R Regulates Short-Term Synaptic Facilitation under Physiological and AD-Related Conditions
Researchers find IGF-1 receptor, “master” lifespan regulator, plays critically important role regulating the transfer of information within neural circuits. They hope their findings can be used to indicate a new direction for therapy used to treat patients in the early stages of Alzheimer’s disease.
The research reveals IGF-1R as a differential regulator of 2 different modes of transmission – spontaneous and evoked – in hippocampal circuits of the brain. “We know that IGF-1R signaling controls growth, development and lifespan, but its role in AD has remained controversial,” said Dr. Slutsky...
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