The IgM antibody has multiple arms to catch the virus, making it more efficient in clumping up the virus and keeping it from passing through the mucosal barrier and entering the rest of the body.
Credit: Graphic artwork: Chris Wager
A group of scientists at Texas Biomedical Research Institute have zeroed in on a new defense against HIV-1, the virus that causes AIDS. Led by Ruth Ruprecht, M.D., Ph.D., the team used an animal model to show for the first time that Immunoglobulin M (IgM) was effective in preventing infection after mucosal AIDS virus exposure. Worldwide, an estimated 90% of new cases of HIV-1 are caused through exposure in the mucosal cavities like the inside lining of the rectum or vagina. “IgM is sort of the forgotten antibody,” Dr...
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