Nischarin mutation inhibits several genes involved in fat metabolism tagged posts

Nischarin Inhibition Alters Energy Metabolism by Activating AMP-Activated Protein Kinase. Journal of Biological Chemistry, 2017; jbc.M117.784256 DOI: 10.1074/jbc.M117.784256

Research has demonstrate protein Nischarin may treat or prevent metabolic diseases including obesity and diabetes. Nischarin is a novel protein discovered by the Alahari lab. The research team demonstrated that it functions as a molecular scaffold that holds and interacts with several protein partners in a number of biological processes. The lab’s earlier research found that Nischarin acts as a tumor suppressor that may inhibit the spread, or metastasis, of breast and other cancers.

The current research project, conducted in a knockout mouse model, found that Nischarin interacts with and controls the activity of a gen...