NKT and CD8 T-cells tagged posts

Healthy liver (left) and diseased liver (right) with infiltrated CD8 T-cells indicated by arrow. Credit: Rohit Kohli, MBBS, MS, Children’s Hospital Los Angeles

Role of NKT and CD8 T-cells demonstrated in mice and humans. A team of investigators led by Rohit Kohli, MBBS, MS, of Children’s Hospital Los Angeles, has identified key inflammatory cells involved in nonalcoholic fatty liver disease. Current treatment for the disorder involves changes to diet, yet no medication has been approved for treatment. Findings from this study provide a potential therapeutic target and offer the possibility for developing a treatment.

“The rise in obesity has led to an epidemic of fatty liver disease in both children and adults,” said Kohli, head of the division of Gastroenterology, Hepatology and Nutrition...