NO synthase (NOS2) tagged posts

Highlights •TNF inhibits IL-4-induced Arg1 expression in macrophages and dendritic cells •Arg1 is upregulated in macrophages or dendritic cells of L. major-infected TNF−/− mice •Arg1 hyperexpression in TNF−/− mice impairs in situ production of leishmanicidal NO •Arg1 deletion restores parasite and disease control in otherwise non-healing mice

Tumour necrosis factor (TNF), a messenger substance in the immune system, plays an important role in triggering chronic inflammatory diseases. For this reason, TNF inhibitors are a standard form of treatment for patients with RA and certain inflammatory bowel diseases. However, TNF also protects against infection, which means that inhibiting it can cause latent infections to resurface...