non-alcoholic fatty liver disease tagged posts

Research is unlocking how the food we eat contributes to an epidemic of chronic liver disease. New research from the University of Missouri School of Medicine has established a link between western diets high in fat and sugar and the development of non-alcoholic fatty liver disease, the leading cause of chronic liver disease.

The research, based in the Roy Blunt NextGen Precision Health Building at MU, has identified the western diet-induced microbial and metabolic contributors to liver disease, advancing our understanding of the gut-liver axis, and in turn the development of dietary and microbial interventions for this global health threat.

“We’re just beginning to understand how food and gut microbiota interact to produce metabolites that contribute to the development of liver...

DNA methylations occur when methyl groups bind to the DNA. These can either activate or inactivate genes. Epigenetic factors modify histone tails by e.g. transferring methyl or acetyl groups on lysine side chains. This can complicate or facilitate the activation of a gene. The direct methylation of the DNA changes the gene expression permanently if it takes place in the control regions of genes (so-called CpG islands), that have been made accessible by the modification of the histones. Credit: Copyright: DIfE

Scientists have shown in a mouse model that the epigenetic* modification of the Igfbp2** gene observed in the young animal precedes a fatty liver in the adult animal later in life...

Metabolic differences in the small intestine A. Metabolic genes as well as the associated reactions involved in the formation of glutathione (GSH) are presented. B, C Significant differences associated with (B) glycine and (C) glutamine are shown. Red and blue arrows indicate the significantly (Q‐value < 0.05) higher and lower expression of the metabolic genes in CONV‐R mice compared to GF mice, respectively. D. The levels of glycine, glutamine, and cysteine used in the de novo synthesis of the GSH are measured in the hepatic portal vein that conducts blood from the gastrointestinal tract to the liver tissue. *Q‐value < 0.05.

Human intestinal flora regulates the levels of the body’s main antioxidant, glutathione, which fights a host of diseases, new research confirms...

SRBAL liver implant and Mayo Expert: Artificial Liver Ready for Human Testing: On any given day about 15,000 Americans are on the liver transplant waiting list, hoping they can get a lifesaving donor organ in time: https://youtu.be/bFLgr3G8ZQg

It supports healing and regeneration of the injured liver, and improve outcomes and reduce mortality rates for patients with acute liver failure. ~30,000-40,000 people die from liver disease each year, according to the American Liver Foundation. For acute liver failure, the only proven treatment has been liver transplantation. Developed by Scott Nyberg, M.D., Ph.D...