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    NAD⁺ restores memory in Alzheimer’s disease models by correcting RNA errors

    November 13, 2025, Categories  Biology/Biotechnology, Health/Medical

    NAD⁺ restores memory in Alzheimer's' disease models by correcting RNA errors
    NR induces transcription of genes involved in axon development, oxygen metabolism, mitochondrion localization, and autophagy in tauopathy mice. GO terms enriched in each of the eight classes of clusters in (A); each circular bar graph represents one cluster or class of clusters, and bar length correlates with the number of DEGs represented. GO terms shown in red font relate to mRNA. Clusters 4 and 5 are similar and are grouped together. Class 1 includes clusters 1, 2, and 6 marked with red. Class 2 includes clusters 4 and 5 marked with orange. Class 3 includes cluster 8 marked with yellow. GTPase, guanosine triphosphatase; NAD(P)H, reduced form of NAD phosphate; IRES, internal ribosomal entry site; GTP, guanosine 5′-triphosphate; MHC, major histocompatibility complex. Credit: Science A...
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    Study suggests method to Boost Growth of Blood Vessels and Muscle

    March 26, 2018, Categories  Biology/Biotechnology, Health/Medical

    An MIT-led research team reversed age-related endurance loss in mice by treating them with a compound that promotes new blood vessel growth.

    An MIT-led research team reversed age-related endurance loss in mice by treating them with a compound that promotes new blood vessel growth.

    Activating proteins linked to longevity may help to increase endurance and combat frailty in the elderly. As we get older, our endurance declines, in part because our blood vessels lose some of their capacity to deliver oxygen and nutrients to muscle tissue. An MIT-led research team has now found that it can reverse this age-related endurance loss in mice by treating them with a compound that promotes new blood vessel growth. The compound, which re-activates longevity-linked proteins called sirtuins, promotes the growth of blood vessels and muscle, boosting the endurance of elderly mice by up to 80%.

    If the findings translate to humans, this restorati...

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