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    nucleophagy tagged posts

    Scientists uncover a Novel Cellular Mechanism that Regulates Aging and Fertility

    December 28, 2022, Categories  Biology/Biotechnology, Health/Medical

    “We have always been intrigued by the dichotomy between two diametrically opposed, fundamental phenomena in biology: soma mortality and germline immortality. The prospect of uncovering the molecular underpinnings of this sharply idiosyncratic character of cell types, within a single organism, provided ample motivation for us to embark on a research journey, towards tackling such questions. We decided to focus on nuclear morphology in somatic cells, which deteriorates during ageing. By contrast, the overall architecture of the nucleus is preserved in the germline. Our hypothesis was that a homeostatic mechanism effectively maintains the structure of germ cell nuclei, whereas it fails during ageing, in the soma...
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