Obesity Therapy tagged posts

Pain Receptors linked to the Generation of Energy-burning Fat cells: implications for Obesity Therapy

Brown adipocytes derived from progenitors expressing the Trpv1 receptor are labeled with Green Fluorescent Protein (GFP) and are found in brown adipose tissue of mice exposed to cold temperature. ( © Joslin Diabetes Center 2021)

A new source of energy-expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) — a protein known to sense noxious stimuli, including pain and temperature.

Specifically, the authors point to smooth muscle cells expressing the Trpv1 receptor...

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