Chronic, low-grade inflammation caused by high fat diets contributes to obesity and type 2 diabetes and other inflammation-related disorders like cardiovascular disease, stroke and rheumatoid arthritis. Prof David Earnest, Ph.D. and his team have shown that consumption of saturated fats at certain times may “jet lag” internal clocks, as well as the resulting inflammation.
Earnest’s previous work suggested that a high-fat diet alters how our body clocks keep time, particularly in immune cells that mediate inflammation. Earlier findings show that a high fat diet slows down the clocks in immune cells such that they no longer “tell” accurate time. Now, he and his team, including Robert S. Chapkin, Ph.D...
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