Northwestern Medicine scientists have discovered that an attenuated (weakened) virus can help eliminate cancer in mice. In addition, mice that were treated with this virus were more resistant to developing tumors later in life.
The attenuated virus—lymphocytic choriomeningitis virus (LCMV)—works and is safe even in immunosuppressed mice. That’s a critical finding, as many cancer patients undergoing chemotherapy and other cancer treatments have suppressed immune systems.
“An important aspect about this viral-based therapy is that it demonstrates safety and efficacy even in an immunosuppressed host,” said corresponding author Pablo Penaloza-MacMaster, an assistant professor of microbiology-immunology at Northwestern University Feinberg School of Medicine...
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