orexin tagged posts

This image shows neural activity during sleep differs between older and younger adults. Credit: Courtesy of Matthew Walker and Bryce Mander

Restorative, sedative-free slumber can ward off mental and physical ailments. As we grow old, our nights are frequently plagued by bouts of wakefulness, bathroom trips and other nuisances as we lose our ability to generate the deep, restorative slumber we enjoyed in youth. But does that mean older people just need less sleep? Not according to UC Berkeley researchers, who argue in an article published April 5 in the journal Neuron that the unmet sleep needs of the elderly elevate their risk of memory loss and a wide range of mental and physical disorders.

“Nearly every disease killing us in later life has a causal link to lack of sleep,” said Matthew Wa...

Euan Ashley and his colleagues discovered an association between heart failure and a pathway linked to narcolepsy. Mark Tuschman

The gene identified by Stanford researchers codes for a protein first identified when a mutated form was shown to cause narcolepsy.
Caring for patients with heart failure costs the US $40 billion a year. Few new treatments have been developed, and those that exist produce varied responses among patients. One major challenge to the development of new treatments has been the lack of genes that can be confidently associated with heart failure. Prof. Euan Ashley is hopeful that the new finding will open doors to evaluating possible treatments.

orexin (hypocretin) neuropeptide precursor

Perez wondered if there were genetic reasons for discrepancies in treatment outcom...

Orexin image provided by researchers. Credit: Image courtesy of University of Tsukuba

A potent compound that promotes wakefulness and remedies the sleep disorder narcolepsy in model animals has been developed by a team of scientists. The compound works to mimic the action of a wake-promoting substance in our brain called “orexin.”.

Orexin, discovered in 1998 by Yanagisawa, is a neuropeptide that plays a central role in maintaining wakefulness. Its deficiency causes narcolepsy, in which patients experience excessive daytime sleepiness, often falling asleep uncontrollably. Patients also suffer from symptoms such as cataplexy (sudden loss of muscle tone triggered by emotion), vivid hallucinations when going into or out of sleep, and sleep paralysis...