osteoblasts tagged posts

A research team, led by Professor Sung Ho Park in the Department of Biological Sciences at UNIST announced the results of a study on osteoblasts that damage joint bones in patients with rheumatoid arthritis.

In this study, the research team studied the possibility of a treatment method targeting mechanisms related to the differentiation process of osteoblasts that melt bones through enzyme reactions. First, it was confirmed that a superinhancer is formed near the NFATC1 gene, which is known to be an important factor in the formation of osteoblasts, and it is formed only in osteoblasts.

In addition, it was confirmed that an enhancer RNA, a type of non-encrypted RNA, is formed in the NFATC1 superinhand during osteoblastic cell formation.

Non-encrypted RNA does not encode protei...

Potential mechanisms contributing to low bone mass and increased fracture susceptibility in diabetes mellitus.

“Clinical trials have revealed a startling elevation in fracture risk in diabetic patients,” says Liyun Wang, associate professor of mechanical engineering at the University of Delaware. “Bone fractures can be life threatening – nearly one in six hip fracture patients dies within a year of injury.” As physical exercise is proven to improve bone properties and reduce fracture risk in non-diabetic people, Wang’s group decided to test its efficacy in Type 1 diabetes.

Osteocytes are critical to maintenance of the tissue quality and mechanical integrity of bone...