ovarian cancer tagged posts

Machine Learning Model builds on Imaging Methods to better Detect Ovarian Lesions

ultrasound images or a benign and a malignant lesion using Zhu's new technique
(From left) The top row shows an ultrasound image of a malignant lesion, the blood oxygen saturation, and hemoglobin concentration. The bottom row is an ultrasound image of a benign lesion, the blood oxygen saturation, and hemoglobin concentration. (Image: Zhu lab)

New research yields a novel method to use ultrasound to enhance machine learning’s ability to accurately diagnose — or rule out — ovarian cancer.

Although ovarian cancer is the deadliest type of cancer for women, only about 20% of cases are found at an early stage, as there are no real screening tests for them and few symptoms to prompt them...

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‘Drug factory’ Implants Eliminate Ovarian, Colorectal Cancer in Mice

Rice University bioengineers Amanda Nash (left) and Omid Veiseh with vials of bead-like “drug factories” they created to treat cancer. The beads are designed to continuously produce natural compounds that program the immune system to attack tumors. (Photo by Jeff Fitlow/Rice University)

Immunotherapy treatment could begin human clinical trials this year. Rice University bioengineers have shown they can eradicate advanced-stage ovarian and colorectal cancer in mice in as little as six days with a treatment that could be ready for human clinical trials later this year.

The researchers used implantable “drug factories” the size of a pinhead to deliver continuous, high doses of interleukin2, a natural compound that activates white blood cells to fight cancer...

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A new way to Target Cancers using ‘Synthetic Lethality’

Three dimensional culture of human breast cancer cells.
Photo credit: NCI Center for Cancer Research.

Approach exploits tumor weaknesses when 2 genetic defects are combined. Researchers report that inhibiting a key enzyme caused human cancer cells associated with two major types of breast and ovarian cancer to die and in mouse studies reduced tumor growth.

With advances in genome sequencing, cancer treatments have increasingly sought to leverage the idea of “synthetic lethality,” exploiting cancer-specific genetic defects to identify targets that are uniquely essential to the survival of cancer cells.

Synthetic lethality results when non-lethal mutations in different genes become deadly when combined in cells.

The research team, led by senior study author Richard D...

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Breakthrough with cancer vaccine

TRI-based Mater researchers in partnership with The University of Queensland have developed a new cancer vaccine, which has shown promising signs in preclinical laboratory studies.

Scientists have developed a new cancer vaccine with the potential to activate the body’s immune system to fight a range of cancers, including leukaemia, breast cancer, lung cancer and pancreatic cancers.

Scientists are ready to trial a new cancer vaccine in humans following the successful outcome of their preclinical studies.

The new vaccine was developed by a Mater Research team based at The Translational Research Institute in collaboration with The University of Queensland.

Lead Researcher Associate Professor Kristen Radford says the vaccine has the potential to treat a variety of blood cancers ...

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