High expression of PHLDB3 is found in multiple cancers and mutually exclusive to TP53 mutations in some cancers.
Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers. The discovery could explain how cancer is able to overcome p53 – a key tumor-suppressing protein. The findings, recently published in Nature Communications, could eventually lead to targeted diagnostic tests and treatments of certain types of cancer.
“Now that we’ve identified the molecule, we could utilize it as an anti-cancer target,” said Dr. Hua Lu, the Reynolds and Ryan Families Chair in Translation Cancer at Tulane...
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