Overcoming Treatment Resistance tagged posts

Dietary Change Starves Cancer Cells, Overcoming Treatment Resistance

Blue green cell microscopic amino
Green staining shows mTORC1 is significantly increased due to disruption in GATOR1 in a mouse model of colon cancer. Credit: Sumeet Solanki, Ph.D.

Laboratory research finds a low-protein diet can enhance standard treatment for colon cancer. A dietary change could be a key to enhancing colon cancer treatment, a new study from the University of Michigan Rogel Cancer Center finds.

Cancer cells need nutrients to survive and grow. One of the most important nutrient sensing molecules in a cell is called mTORC1. Often called a master regulator of cell growth, it allows cells to sense different nutrients and thereby grow and proliferate. When nutrients are limited, cells dial down nutrient sensing cascade and turn off mTORC1.

While mTORC1 is known to be hyperactive in colon cancer, the k...

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