oxic metabolites tagged posts

Scientists identify Gut-derived Metabolites that play a role in Neurodegeneration

A new study has identified gut-derived metabolites that appear to be neurotoxic and play a role in the progression of multiple sclerosis. Credit: Nicoletta Barolini

A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples of multiple sclerosis (MS) patients. The important findings, published in the journal Brain, further scientists’ understanding of how gut bacteria can impact the course of neurological diseases by producing compounds that are toxic to nerve cells.

Previously published evidence has supported the concept that an imbalance in the gut microbiota—the community of organisms that live in the human intestines—may underly a range of neurological disorders...

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