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    oxidative damage tagged posts

    New Pathway for Accumulation of Age-promoting ‘Zombie Cells’

    July 12, 2022, Categories  Biology/Biotechnology, Health/Medical

    X-shaped chromosomes are stained purple, and telomeres appear as green spots at chromosome tips. When researchers used a novel tool to induce oxidative damage specifically at telomeres, they can become fragile (green arrows), sending cells into senescence. The inset shows an enlarged chromosome with fragile telomeres, indicated by multiple green spots at chromosome tips.

    Senescent cells — those that have lost the ability to divide — accumulate with age and are key drivers of age-related diseases, such as cancer, dementia and cardiovascular disease. In a new study, a team led by University of Pittsburgh and UPMC Hillman Cancer Center researchers has uncovered a mechanism by which senescent, or “zombie,” cells develop.

    Published today in Nature Structural & Molecular Biology, the stud...

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